Paddington has grown up deep in the Peruvian jungle with his Aunt Lucy who, inspired by a chance encounter with an English explorer, has raised her nephew to dream of an exciting life in London. When an earthquake destroys their home, Aunt Lucy decides to smuggle her young nephew on board a boat bound for England, in search of a better life. Arriving alone at Paddington Station, Paddington soon finds that city life is not all he had imagined - until he meets the kindly Brown family, who find him with a label tied around his neck which reads 'Please look after this bear. Thank you.' They offer him a temporary home whilst he searches for the explorer who impressed Aunt Lucy all those years before.

But when Paddington catches the eye of a sinister, seductive taxidermist, it isn't long before his home - and very existence - is under threat ...