David, an author in his mid-30s, travels to the Greek island of Tinos with his wife Nina to spend time in a secluded beach house in the off-season. While David searches for inspiration for his new novel, Nina is looking for a new spark in their life. On the first night, David hears noises from the living room and prepares to fight a burglar. But to his surprise, he instead finds Margarita, the daughter of the owner of the house, who knew nothing of the foreign renters. One night on the couch for Margarita soon turns into several as the freshly minted trio comes together. When Margarita disappears, however, the young couple will have to face the unexpected consequences of their relations. Rest in Greece is a partly improvised, erotically charged film about human relationships.